No siree(, Bob)!
Inf. Absolutely no! (Not necessarily said to a male, and rarely to any Bob.) Bill: Do you want to sell this old rocking chair? Jane: No siree, Bob! Bill: You don't want sweet potatoes, do you? Fred: No siree!
Yes siree(, Bob)!
Inf. Absolutely!; Without a doubt! (Not necessarily said to a male and not necessarily to Bob.) Mary: Do you want some more cake? Tom: Yes siree, Bob! "That was a fine turkey dinner. Yes siree!" said Uncle Henry.