From the name of a barrio (district) in Seville, which got its name from a temple which may have been named for a person Macarius (see MACARIO). The Virgin of Macarena, that is Mary, is widely venerated in Seville.
Spanish form of the Latin name Macarius, derived from the Greek name Μακαριος (Makarios), which was in turn derived from Greek μακαρ (makar) meaning "blessed, happy". This was the name of several early saints.