In a position of highest importance or priority. The new company I work for is at the forefront of medical innovation. I think some of their new instruments are going to revolutionize the field of medicine.My kids' safety is always a concern at the forefront of my mind.
Fig. at the place of greatest activity; vital or important to some activity. I interviewed Max Brown, the director who is in the forefront of the movie industry.The university I go to is at the forefront of computer technology.