1. and shoot up tv. & in. to inject drugs, especially heroin. (Drugs.) He actually had to leave the meeting to shoot.
2. n. an injection of heroin. (Drugs. Usually shoot-up.) The way Ernie was yawning, I knew he needed a shoot-up.
3. tv. to spike a drink with liquor. I’m gonna shoot the punch with rum.
4. in. to begin to tell [something]. Okay, shoot. I’m all ears.
5. exclam. Darn! (Usually Shoot! An exclamation or a very mild curse. A substitute if not a euphemism for shit.) Oh, shoot! I left my shades in the car.