| Epifanio | | e-pee-FAH-nyo | Spanish, Italian | |
| Erasmo | | - | Italian, Spanish, Portuguese | |
| Ercilia | | - | Spanish | |
| Eric | | ER-ik (English) | English, Swedish, German, Spanish | |
| Ernesto | | - | Italian, Spanish, Portuguese | |
| Esmeralda | | es-me-RAHL-dah (Spanish), esh-mə-RAL-də (Portuguese), ez-mə-RAHL-də (English) | Spanish, Portuguese, English, Literature | |
| Esperanza | | es-pe-RAHN-thah (Spanish), es-pe-RAHN-sah (Latin American Spanish) | Spanish | |
| EspiridiÓN | | - | Spanish | |
| Estavan | | - | Spanish | |
| Esteban | | es-TE-bahn | Spanish | |
| EstefanÍA | | es-te-fah-NEE-ah | Spanish | |
| Estela | | - | Portuguese, Spanish | |
| Ester | | ES-ter (Finnish) | Spanish, Portuguese, Czech, Swedish, Norwegian, Danish, Icelandic, Finnish | |
| Esther | | ES-tər (English, Dutch), es-TER (French) | English, French, Spanish, Dutch, German, Danish, Norwegian, Swedish, Jewish, Biblical, Biblical Lati | |
| Estrella | | es-TRE-yah | Spanish | |