| Emilio | | e-MEE-lyo (Italian, Spanish) | Italian, Spanish, Portuguese | |
| Emma | | EM-ə (English), EM-mah (Finnish), E-mah (German) | English, French, Italian, Spanish, Swedish, Norwegian, Danish, Icelandic, Finnish, Dutch, German, An | |
| Emperatriz | | em-pe-rah-TREETH (Spanish), em-pe-rah-TREES (Latin American Spanish) | Spanish | |
| Encarna | | en-KAHR-nah | Spanish | |
| EncarnaciÓN | | en-kahr-nah-THYON (Spanish), en-kahr-nah-SYON (Latin American Spanish) | Spanish | |
| Encarnita | | en-kahr-NEE-tah | Spanish | |
| Eneida | | - | Portuguese (Brazilian), Spanish (Latin American) | |
| Enrique | | en-REE-ke | Spanish | |
| Epifanio | | e-pee-FAH-nyo | Spanish, Italian | |
| Erasmo | | - | Italian, Spanish, Portuguese | |
| Ercilia | | - | Spanish | |
| Eric | | ER-ik (English) | English, Swedish, German, Spanish | |
| Ernesto | | - | Italian, Spanish, Portuguese | |
| Esmeralda | | es-me-RAHL-dah (Spanish), esh-mə-RAL-də (Portuguese), ez-mə-RAHL-də (English) | Spanish, Portuguese, English, Literature | |
| Esperanza | | es-pe-RAHN-thah (Spanish), es-pe-RAHN-sah (Latin American Spanish) | Spanish | |