| Santos | | SAHN-tos | Spanish | |
| Sara | | SAH-rah (Spanish, Finnish, Dutch, Polish), ZAH-rah (German), SER-ə (English), SAR-ə (English), SAH:-rah (Arabic) | Greek, Spanish, Italian, Portuguese, Catalan, Swedish, Norwegian, Danish, Icelandic, Finnish, German | |
| Sarita (1) | | - | Spanish | |
| Saturnina | | sah-toor-NEE-nah (Spanish) | Ancient Roman, Spanish | |
| Saturnino | | sah-toor-NEE-no (Spanish, Italian) | Spanish, Italian, Portuguese | |
| SebastiÁN | | se-bah-STYAHN | Spanish | |
| Selena | | - | Spanish, Russian, Greek Mythology (Latinized) | |
| Sence | | - | Medieval Spanish | |
| Sens | | - | Medieval Spanish | |
| Septima | | - | Ancient Roman, Spanish | |
| Serafina | | se-rah-FEE-nah (Polish) | Italian, Portuguese, Spanish, Polish | |
| Sergio | | SER-jo (Italian), SER-khyo (Spanish) | Italian, Spanish | |
| Seve | | SE-ve | Spanish | |
| Severiano | | se-ve-RYAH-no | Italian, Spanish | |
| Severino | | se-ve-REE-no (Italian, Spanish) | Italian, Spanish, Portuguese | |