| Sarra | | - | Biblical Greek, Biblical Latin, Old Church Slavic | |
| Selena | | - | Spanish, Russian, Greek Mythology (Latinized) | |
| Selene | | sə-LEE-nee (English) | Greek Mythology, Greek | |
| Seleucus | | - | Ancient Greek (Latinized) | |
| Seleukos | | - | Ancient Greek | |
| Sem | | SEM (Dutch) | Biblical Latin, Biblical Greek, Dutch | |
| Semele | | - | Greek Mythology | |
| Sepphora | | - | Biblical Greek | |
| Serafeim | | - | Greek | |
| Seth (1) | | SETH (English) | English, Biblical, Biblical Latin, Biblical Greek | |
| Sibylla | | zi-BUY-lah (German) | Greek, German, Swedish, Late Roman, Late Greek | |
| Silas | | SIE-ləs (English) | English, Greek, Biblical, Biblical Latin, Biblical Greek | |
| Silouanos | | - | Biblical Greek | |
| Simonides | | - | Ancient Greek | |
| Socrates | | SAHK-rə-teez (English) | Ancient Greek (Latinized) | |