| Rossella | | ros-SEL-lah | Italian | |
| Rubina | | - | Italian | |
| Rufino | | roo-FEE-no (Italian, Spanish) | Italian, Spanish, Portuguese | |
| Ruggero | | rood-JE-ro | Italian | |
| Ruggiero | | rood-JYE-ro | Italian | |
| Sabina | | sah-BEE-nah (Italian, Spanish, Polish) | Italian, Spanish, Portuguese, Romanian, Polish, Czech, Slovene, Russian, Croatian, Ancient Roman | |
| Sabino | | - | Italian | |
| Sabrina | | sə-BREEN-ə (English), sah-BREE-nah (Italian), zahp-REE-nah (German) | English, Italian, German | |
| Salvatore | | sahl-vah-TO-re | Italian | |
| Salvatrice | | - | Italian | |
| Samanta | | - | Italian, Spanish | |
| Samantha | | sə-MAN-thə (English) | English, Italian, Dutch | |
| Samuela | | - | Italian | |
| Samuele | | sah-MWE-le | Italian | |
| Sandra | | SAHN-drah (Italian, Dutch, Finnish), SAN-drə (English), ZAHN-drah (German) | Italian, English, French, Spanish, Portuguese, German, Dutch, Swedish, Norwegian, Danish, Icelandic, | |