| Scilla | | - | Italian | |
| Sebastiana | | - | Italian | |
| Sebastiano | | - | Italian | |
| Selvaggia | | - | Italian | |
| Serafina | | se-rah-FEE-nah (Polish) | Italian, Portuguese, Spanish, Polish | |
| Serafino | | - | Italian | |
| Serena | | sə-REEN-ə (English), se-RE-nah (Italian) | English, Italian, Late Roman | |
| Sergio | | SER-jo (Italian), SER-khyo (Spanish) | Italian, Spanish | |
| Sesto | | - | Italian | |
| Settimio | | - | Italian | |
| Severiano | | se-ve-RYAH-no | Italian, Spanish | |
| Severina | | - | Italian, Portuguese, Croatian, German, Ancient Roman | |
| Severino | | se-ve-REE-no (Italian, Spanish) | Italian, Spanish, Portuguese | |
| Severo | | se-VE-ro | Italian, Spanish | |
| Sibilla | | - | Italian | |